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Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions.
- Source :
-
European Journal of Nuclear Medicine & Molecular Imaging . Jul2007 Supplement, Vol. 34, p1-8. 8p. 1 Color Photograph, 3 Diagrams, 2 Graphs. - Publication Year :
- 2007
-
Abstract
- Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte–macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 34
- Database :
- Academic Search Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 25449261
- Full Text :
- https://doi.org/10.1007/s00259-007-0435-0