Leucoencéphalite multifocale progressive en dehors du sida: efficacité de l'association cytarabine–cidofovir

Abstract: Introduction: Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system, occurring in immunocompromised patients. Treatment, not codified to date, is more often inefficient with a rapid and fatal deterioration. Case record: A 48-year-old woman, treated with immunosuppressant agents for systemic lupus, presented with PML mimicking neurolupus flare. A complete remission was obtained with cytarabine and cidofovir. Conclusion: Combined cytarabine and cidofovir appears a promising therapeutic option in PML associated with autoimmune systemic disorders. [Copyright &y& Elsevier]