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Compared fate of small-diameter Contegras® and homografts in the pulmonary position
- Source :
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European Journal of Cardio-Thoracic Surgery . Aug2007, Vol. 32 Issue 2, p209-214. 6p. - Publication Year :
- 2007
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Abstract
- Abstract: Objective: This study analyzes whether small-diameter Contegras behave in the same way as small-diameter homografts, when implanted for the first time in pulmonary position. Methods: Small-diameter conduits include 12 and 14mm Contegras and 8–14mm homografts. Graft dysfunction is defined as right ventricular outflow tract obstruction with peak echo-Doppler gradient>40mmHg, or grade III/IV graft regurgitation. Graft failure is defined as need for conduit replacement or need for catheter or surgical reintervention. Thirty-eight patients who received small Contegras (n =25) and small homografts (n =13) from October 2002 to end December 2006 were studied. The most frequent indication was pulmonary atresia and ventricular septal defect (n =20; 10 associated with major aorto-pulmonary collateral arteries), followed by truncus arteriosus (n =12). Most patients’ characteristics were comparable except that recipients of homografts were smaller (p for body area=0.014). Survival, freedom from graft dysfunction, failure and explantation were estimated by the Kaplan–Meier method. The log-rank test was used to compare outcomes. Results: There were three early and four late deaths. No death was graft related. Survival was 80±8.2% for patients with Contegras and 77±11.7% for those with allografts: p =0.82. Mean follow-up duration is 22±16 months. Freedom from dysfunction for Contegra conduits decreased in the first 6 months and stabilized at 58±11% from month 14. For homografts it decreased only 1 year after implantation, down to 35±19.7% from month 31: p =0.61. Freedom from Contegra failure diminished the first 16 months to level out at 57±13%. No homograft failed the first 2 years. With a p-value of 0.14, homografts tended to fail less frequently. Five grafts were explanted. Freedom from explantation was similar (p =0.98): 90±6.7% for Contegras and 75±21.6% for homografts at year 3. Conclusion: In the first 4 years after pulmonary implantation of small-diameter Contegras and homografts, the fate of both conduits was statistically similar, in spite of different behavior. As Contegra is ‘off-the-shelf’ available, it constitutes a sound alternative to homograft for right ventricular outflow tract reconstruction in neonates and infants. [Copyright &y& Elsevier]
- Subjects :
- *SURGERY
*MEDICINE
*LIFE sciences
*BIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 10107940
- Volume :
- 32
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Cardio-Thoracic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 25619094
- Full Text :
- https://doi.org/10.1016/j.ejcts.2007.04.036