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Oxytocin antagonists may improve infertility treatment
- Source :
-
Fertility & Sterility . Jul2007, Vol. 88 Issue 1, p213-213. 1p. - Publication Year :
- 2007
-
Abstract
- Objective: To confirm the improvement of uterine receptivity following administration of oxytocin and vasopressin V1A antagonist atosiban. Design: Case report. Setting: Private reproductive medicine center. Patient(s): A 42-year-old woman with a history of 15 years’ infertility and seven failed in vitro fertilization/embryo transfer (IVF-ET) attempts. Intervention(s): Atosiban (mixed vasopressin V1A/oxytocin antagonist registered for the treatment of imminent premature birth) was administered on the 14th day of endometrial synchronization for oocyte donation. Main Outcome Measure(s): Uterine contractile activity (component of uterine receptivity) and success of treatment of infertility. Result(s): Intense spontaneous uterine contractility was visualized by transvaginal sonography. After 1 hour of intravenous infusion of atosiban, a repeated scan showed a significant decrease in contractile activity (11 vs 7 contractions per 4 minutes, respectively). The ET was performed immediately after, and the infusion of atosiban continued for the next 2 hours. The treatment decreased the uterine contractile activity and resulted in successful embryo implantation and a normal twin diamniotic pregnancy. Conclusion(s): Atosiban may improve uterine receptivity during ET and may increase success rates of advanced infertility treatment procedures. [Copyright &y& Elsevier]
- Subjects :
- *MEDICAL research
*MEDICAL sciences
*LIFE sciences
*BIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 88
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 25627485
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2006.09.017