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AIRWAY INFLAMMATORY RESPONSES TO OXIDATIVE STRESS INDUCED BY LOW-DOSE DIESEL EXHAUST PARTICLE EXPOSURE DIFFER BETWEEN MOUSE STRAINS.
- Source :
-
Experimental Lung Research . Jun/Jul2007, Vol. 33 Issue 5, p227-244. 18p. - Publication Year :
- 2007
-
Abstract
- Low-dose diesel exhaust particle (DEP) exposure induces airway inflammation and exaggerates asthmatic responses in mice, but it is unclear whether strains differ in their susceptibility to adverse effects from low-dose DEP exposure. The authors used BALB/c and C57BL/6 mouse strains to search for genetically based differences in response to low-dose DEP (100 µg/m3) exposure in terms of airway inflammatory response. The macrophage count in bronchoalveolar lavage (BAL) fluid soon after DE exposure began was significantly greater in C57BL/6 mice (P < .05) than that in BALB/c mice. The count did not increase significantly in BALB/c mice until later. Heme oxygenase-1 (HO-1) mRNA expression and protein production in lung tissues soon after exposure began were more marked in BALB/c mice than in C57BL/6 mice, but the reverse was true later on. The increases in interleukin (IL)-1β and interferon (IFN)-γ levels in BAL fluid after DE exposure were significant only in BALB/c mice; there were significantly increases in monocyte chemoattractant protein (MCP)-1, IL-12, IL-10, IL-4, and IL-13 in both strains, but these were more marked in C57BL/6 mice. These interstrain differences in airway inflammatory response after DE exposure were significantly attenuated by antioxidant N-acetylcysteine (NAC) treatment. Changes in airway hyperresponsiveness were independent of the airway inflammation induced by low-dose DEP. Thus, in BALB/c mice, innate immunity may play a central role in DE exposure response, whereas in C57BL/6 mice Th2-dominant responses play a central role. Low-dose DEP exposure induces airway inflammatory responses that differ among strains, and these differences may be caused by differences in sensitivity to oxidative stress. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIESEL motor exhaust gas
*AIRWAY (Anatomy)
*INFLAMMATION
*OXIDATIVE stress
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 01902148
- Volume :
- 33
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Experimental Lung Research
- Publication Type :
- Academic Journal
- Accession number :
- 25728029
- Full Text :
- https://doi.org/10.1080/01902140701481062