N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors

Authors :: Parker, Michael F.
Barten, Donna M.
Bergstrom, Carl P.
Bronson, Joanne J.
Corsa, Jason A.
Deshpande, Milind S.
Felsenstein, Kevin M.
Guss, Valerie L.
Hansel, Steven B.
Johnson, Graham
Keavy, Daniel J.
Lau, Wai Y.
Mock, Jeremy
Prasad, C.V.C.
Polson, Craig T.
Sloan, Charles P.
Smith, David W.
Wallace, Owen B.
Wang, Henry H.
Williams, Andrew
Source :: Bioorganic & Medicinal Chemistry Letters. Aug2007, Vol. 17 Issue 16, p4432-4436. 5p.
Publication Year :: 2007
Abstract: Abstract: A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo γ-secretase activity. [Copyright &y& Elsevier]

Subjects :: *ALKYLBENZENE sulfonates
*SULFONAMIDES
*METHANOL
*DRUG development

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