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SAP discovery : The sword edges — Beneficial and harmful
- Source :
-
Autoimmunity Reviews . Aug2007, Vol. 6 Issue 7, p444-449. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: We cloned the SLAM associated protein (SAP) gene in 1995. In 1998, it was discovered that the SAP gene was defective in patients with X-linked lymphoproliferative disease. Subsequently, details on the key role of life-long immune memory (vaccination) and of life-long autoantibody production in patients suffering from autoimmune disease have been revealed. In this paper, we discuss the dual nature of SAP in humans: its beneficial effect on life-long immune memory (vaccination) and its harmful effect on life-long autoantibody production. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15689972
- Volume :
- 6
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Autoimmunity Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 25827368
- Full Text :
- https://doi.org/10.1016/j.autrev.2007.01.015