Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways

Abstract: Apoptosis is mediated via death receptor, the mitochondrial, and the endoplasmic reticulum pathway. Following activation of naïve T cells with antigens, different subsets of memory T cells are generated. In this review we have discussed relative sensitivity/resistance of naïve and different subsets of memory T cells to apoptosis via different signaling pathways. Molecular basis for differential sensitivity to apoptosis is discussed. [Copyright &y& Elsevier]