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Modeling the interactions between compliant microcapsules and pillars in microchannels.
- Source :
-
Journal of Chemical Physics . 7/21/2007, Vol. 127 Issue 3, p034703. 10p. 4 Diagrams, 2 Charts, 5 Graphs. - Publication Year :
- 2007
-
Abstract
- Using a computational model, we investigate the motion of microcapsules inside a microchannel that encompasses a narrow constriction. The microcapsules are composed of a compliant, elastic shell and an encapsulated fluid; these fluid-filled shells model synthetic polymeric microcapsules or biological cells (e.g., leukocytes). Driven by an imposed flow, the capsules are propelled along the microchannel and through the constricted region, which is formed by two pillars that lie in registry, extending from the top and bottom walls of the channels. The tops of these pillars (facing into the microchannel) are modified to exhibit either a neutral or an attractive interaction with the microcapsules. The pillars (and constriction) model topological features that can be introduced into microfluidic devices or the physical and chemical heterogeneities that are inherently present in biological vessels. To simulate the behavior of this complex system, we employ a hybrid method that integrates the lattice Boltzmann model (LBM) for fluid dynamics and the lattice spring model (LSM) for the micromechanics of elastic solids. Through this LBM/LSM technique, we probe how the capsuleās stiffness and interaction with the pillars affect its passage through the chambers. The results yield guidelines for regulating the movement of microcarriers in microfluidic systems and provide insight into the flow properties of biological cells in capillaries. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARTIFICIAL cells
*LEUCOCYTES
*MICROFLUIDICS
*FLUID dynamics
*MICROMECHANICS
Subjects
Details
- Language :
- English
- ISSN :
- 00219606
- Volume :
- 127
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Physics
- Publication Type :
- Academic Journal
- Accession number :
- 25906332
- Full Text :
- https://doi.org/10.1063/1.2753150