Design, 'one-pot' synthesis, characterization, antibacterial and antifungal activities of novel 6-aryl-1,2,4,5-tetrazinan-3-thiones in dry media.

A novel 'one-pot' synthesis of 6-aryl-1,2,4,5-tetrazinan-3-thiones is carried out by the three-component coupling of thiourea, various structurally diverse aromatic aldehydes and ammonium acetate in the presence of reusable NaHSO4·SiO2 heterogeneous catalyst in dry media under microwave irradiation. FT-IR, 1H NMR, D2O Exchange, HOMOCOR, 13C NMR, MS and elemental analysis characterize all the synthesized compounds. In vitro antibacterial/fungal activities are carried out for all the synthesized eight new compounds. All the compounds are more active against bacterial strains namely Staphylococcus aureus, β-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, Shigella felxneri, Klebsiella pneumonia and Pseudomonas except compounds 1 and 6, while compound 6 shows promising activity against Salmonella typhii. Moreover, of all the compounds tested, compounds 3 and 8 are more effectual against all the tested fungal strains. [ABSTRACT FROM AUTHOR]