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Inhaled Corticosteroids and Long-Acting β2-Agonists in Treatment of Patients with Chronic Bronchiolitis Following Exposure to Sulfur Mustard.
- Source :
-
Inhalation Toxicology . Aug2007, Vol. 19 Issue 10, p889-894. 6p. 1 Diagram, 3 Charts, 3 Graphs. - Publication Year :
- 2007
-
Abstract
- We examined the role of two regimens of combination inhaler therapy on amount of reversibility of chronic lung complications in mustard gas exposed patients. In a phase III, prospective, randomized clinical trial, 105 participants received either combination form of fluticasone propionate and salmetrol, 500/100 μ g daily (group 1; n = 52) or beclomethasone, 1000 μ g daily, and salbutamol inhaler, 800 μg daily (group 2; n = 53) for 12 wk. Pulmonary function test (PFT) indices and respiratory symptoms (including dyspnea, night awakening due to dyspnea and cough) were assessed at baseline and in each visit. Thirty-six patients in group 1 and 30 patients in group 2 completed study course. Both medication regimes increased pretreatment forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC%, and peak expiratory force (PEF) by the end of 12 wk. It seems that these improvements are more constant in group 1 than in group 2. Reversibility, that is, 10% increase of FEV1 in the second month was seen for 27% of patients in the group 1 and for 7% in the group 2. VAS scores have decreased in two groups during treatment period (p = .003) and after follow-up period it remained sustained in group 1 alone. Inhaled corticosteroids and long-acting β 2-agonists are effective in treatment of patients with chronic bronchiolitis following exposure to sulfur mustard. However, a medium dose of fluticasone/salmeterol has the same effect on the airways reversibility, rather than a very high dose of beclomethasone with only the short-acting beta-agonist. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08958378
- Volume :
- 19
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Inhalation Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 26100102
- Full Text :
- https://doi.org/10.1080/08958370701432132