HİPERTANSİF HASTALARDA SOL VENTRİKÜL HİPERTROFİSİ GELİŞMESİNE LEPTİN DÜZEYLERİNİN ETKİSİ.

• Aims: Leptin, which is a hormone secreted by adipose tissue, has many effects on the sympathetic nervous system and other systems. It is well-known that hypertension is associated with high leptin levels. The aim of this study was to determine whether there is any effect of leptin on the development of left ventricular hypertrophy(LVH) in hypertensive patients. • Material and methods: Forty hypertensive patients were enrolled to the study. The study population was divided into two groups according to LVH determined by echocardiography. Group 1 was consisted of 27 hypertensive patients with LVH(m/f: 9/18, the mean age:59.1±7.2yrs) while group 2 was composed of 13 hypertensive patients without LVH (m/f: 5/8,the mean age:62.4±4.9yrs). The blood samples was taken at fasting state and serums were kept at -80°C until examined. Plasma leptin levels were determined by ELISA. The clinical and echocardiographic parameters and the mean plasma leptin levels were compared to each other. • Results: We did not find any statistical significance between groups in terms of the treatment, the duration of hypertension and body mass index. The mean plasma leptin levels was 33.3±15.3 ng/ml in the group 1 whereas this was 28.3±17.6 ngr/ml in the group 2. There was not any statistical difference between them (p>0.05). • Conclusion: The plasma leptin levels in hypertensive patients with LVH was not different from that in hypertensive patients without LVH. It may be concluded that there is not any effect of leptin on the development of LVH in hypertension. [ABSTRACT FROM AUTHOR]