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Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.
- Source :
-
Nature Chemical Biology . Sep2007, Vol. 3 Issue 9, p559-564. 6p. 4 Diagrams, 2 Graphs. - Publication Year :
- 2007
-
Abstract
- Glycosphingolipids (GSLs) from the Sphingomonadaceae family of bacteria have been reported to be potent stimulators of natural killer T cells. These glycolipids include mono-, tri- and tetraglycosylceramides. Here we have prepared the GSL-1 to GSL-4 series of glycolipids and tested their abilities to stimulate natural killer T cells. Among these glycolipids, only GSL-1 (1) is a potent stimulator. Using a series of synthetic diglycosylceramides, we show that oligoglycosylceramides from Sphingomonadaceae are not effectively truncated to GSL-1 in lysosomes in antigen-presenting cells, possibly because the higher-order GSLs are poor substrates for lysosomal acyltransfer enzymes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLYCOSPHINGOLIPIDS
*BACTERIA
*T cells
*KILLER cells
*GLYCOLIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 15524450
- Volume :
- 3
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Nature Chemical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 26271166
- Full Text :
- https://doi.org/10.1038/nchembio.2007.19