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Intravenous polymyxin B for the treatment of nosocomial pneumonia caused by multidrug-resistant Pseudomonas aeruginosa

Authors :
Furtado, Guilherme Henrique Campos
d’Azevedo, Pedro Alves
Santos, Anderson Fernandes
Gales, Ana Cristina
Pignatari, Antônio Carlos Campos
Medeiros, Eduardo Alexandrino Servolo
Source :
International Journal of Antimicrobial Agents. Oct2007, Vol. 30 Issue 4, p315-319. 5p.
Publication Year :
2007

Abstract

Abstract: Nosocomial pneumonia caused by multidrug-resistant (MDR) Pseudomonas aeruginosa is becoming increasingly prevalent throughout the world. The use of polymyxins to treat these infections has greatly increased. We analysed 74 patients with nosocomial pneumonia caused by MDR P. aeruginosa who were treated with polymyxin B. A favourable outcome was observed in 35 patients (47.3%). A case–control study was performed to assess the variables associated with an unfavourable outcome. The presence of acute respiratory distress syndrome (odds ratio (OR)=11.29, 95% confidence interval (CI) 2.64–48.22; P =0.001) and septic shock (OR=4.81, 95% CI 1.42–16.25; P =0.01) were independently associated with an unfavourable outcome in patients with nosocomial pneumonia due to MDR P. aeruginosa. Our study demonstrated that polymyxin B is a reliable antimicrobial drug, but only as salvage therapy, for nosocomial pneumonia caused by MDR P. aeruginosa. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
09248579
Volume :
30
Issue :
4
Database :
Academic Search Index
Journal :
International Journal of Antimicrobial Agents
Publication Type :
Academic Journal
Accession number :
26488064
Full Text :
https://doi.org/10.1016/j.ijantimicag.2007.05.017