Back to Search
Start Over
Synthesis of chlorogenic acid derivatives with promising antifungal activity
- Source :
-
Bioorganic & Medicinal Chemistry . Nov2007, Vol. 15 Issue 21, p6830-6833. 4p. - Publication Year :
- 2007
-
Abstract
- Abstract: Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus. [Copyright &y& Elsevier]
- Subjects :
- *ASPERGILLUS
*CANDIDIASIS
*ASPERGILLUS fumigatus
*CANDIDA albicans
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 15
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26570478
- Full Text :
- https://doi.org/10.1016/j.bmc.2007.07.038