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TrkC: A New Predictive Marker in Breast Cancer?
- Source :
-
Cancer Investigation . Sep2007, Vol. 25 Issue 6, p405-410. 6p. 1 Black and White Photograph, 3 Graphs. - Publication Year :
- 2007
-
Abstract
- Available data involve neurotrophins and their receptors in carcinomas. Quantitative evaluation of these molecules in these tumors might be useful as prognostic marker and eventual treatments. Our study on 40 mammary tumors tries to correlate expression of these molecules and prognosis. Immunohistochemistry for NGF, BDNF, NT3, TrkA, TrkB, TrkC, and p75 was used. Patient's age, histopathology, Bloom-Richardson grading, estrogen and progesterone receptors, Ki-67 index, HER-2, p53 were evaluated. Statistics found inverse relationship between grading and TrkC expression. We found significantly higher TrkC expression in Grade I than in Grade III tumors. Rise in TrkC expression could indicate good prognosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST cancer
*HORMONE receptors
*CANCER patients
*CANCER treatment
*HISTOPATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 25
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 26640894
- Full Text :
- https://doi.org/10.1080/07357900701206349