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A bcr-3 isoform of RAR...-PML potentiates the development of PML-RAR...-driven acute...

Authors :
Pollock, Jessica L.
Westervelt, Peter
Source :
Proceedings of the National Academy of Sciences of the United States of America. 12/21/99, Vol. 96 Issue 26, p15103. 6p. 1 Color Photograph, 1 Black and White Photograph, 1 Chart, 3 Graphs.
Publication Year :
1999

Abstract

Presents a study which aimed to investigate the biological role of a bcr-3 isoform of RAR...-PML for the development of acute promyelocytic leukemia (APML) in a transgenic mouse model. Information on APML; Construction of the transgene; Detection of transgene expression in bone marrow cells; Treatment of APML cells in vitro; Results.

Subjects

Subjects :
*LEUKEMIA
*TRANSGENIC mice

Details

Language :
English
ISSN :
00278424
Volume :
96
Issue :
26
Database :
Academic Search Index
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
2664187
Full Text :
https://doi.org/10.1073/pnas.96.26.15103