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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma
- Source :
-
Cancer Letters . Oct2007, Vol. 256 Issue 2, p196-206. 11p. - Publication Year :
- 2007
-
Abstract
- Abstract: We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma. [Copyright &y& Elsevier]
- Subjects :
- *APOPTOSIS
*CELL death
*LYMPHOMAS
*RECEPTOR antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 256
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 26681665
- Full Text :
- https://doi.org/10.1016/j.canlet.2007.06.001