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High prevalence of major cardiovascular risk factors in first-degree relatives of individuals with familial premature coronary artery disease—The GENECARD project
- Source :
-
Atherosclerosis (00219150) . Sep2007, Vol. 194 Issue 1, p253-264. 12p. - Publication Year :
- 2007
-
Abstract
- Abstract: Background: Hypertension, hypercholesterolemia, obesity and smoking are highly prevalent among patients with familial premature coronary artery disease (FP-CAD). Whether these risk factors equally affect other family members remains unknown. Methods: We examined 222 FP-CAD patients, 158 unaffected sibs, 197 offspring and 94 spouses in 108 FP-CAD families (≥2 sibs having survived CAD diagnosed before age 51 (M)/56 (F)), and compared them to population controls. Results: Unaffected sibs had a higher prevalence of hypertension (49% versus 24%, p <0.001), hypercholesterolemia (47% versus 34%, p =0.002), abdominal obesity (35% versus 24%, p =0.006) and smoking (39% versus 24%, p =0.001) than population controls. Offspring had a higher prevalence of hypertension (females), hypercholesterolemia and abdominal obesity than population controls. No difference was observed between spouses and controls. Compared to unaffected sibs, FP-CAD affected sibs had a similar risk factor profile, except for smoking, which was more prevalent (76% versus 39%, p =0.008). Conclusions: Hypertension, obesity and hypercholesterolemia are highly prevalent among first-degree relatives, but not spouses, of patients with FP-CAD. These persons deserve special medical attention due to their familial/genetic susceptibility to atherogenic metabolic abnormalities. In these families, smoking may be the trigger for FP-CAD. [Copyright &y& Elsevier]
- Subjects :
- *CORONARY arteries
*HEART blood-vessels
*BODY weight
*HYPERCHOLESTEREMIA
Subjects
Details
- Language :
- English
- ISSN :
- 00219150
- Volume :
- 194
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Atherosclerosis (00219150)
- Publication Type :
- Academic Journal
- Accession number :
- 26842135
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2006.08.004