Determinants of Virologic and Immunologic Outcomes in Chronically HIV-Infected Subjects Undergoing Repeated Treatment Interruptions: The Istituto Superiore di Sanità-Pulsed Antiretroviral Therapy (ISS-PART) Study.

The article presents a randomized study which determines the factors that influence the virologic and immunologic outcome of structured interruptions (STIs) in HIV chronic infection. The main outcome measures of the study was aimed at testing the noninferiority of STIs to continuous highly active antiretroviral therapy (HAART) in terms of CD4 cell count. The results of the study is presented and discussed.