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Biological studies of organotin(<span style="font-variant:small-caps">IV</span> ) complexes with 2-mercaptopyrimidine.
- Source :
-
Russian Chemical Bulletin . Apr2007, Vol. 56 Issue 4, p767-773. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract  The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bun 2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1â4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2â4 was demonstrated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANOTIN compounds
*PEROXIDATION
*FATTY acids
*LIPOXYGENASES
Subjects
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 56
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 27011463
- Full Text :
- https://doi.org/10.1007/s11172-007-0115-z