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A concise synthesis of 4,6-dideoxy-4-base-6-amino-2,5-anhydro-l-mannitols
- Source :
-
Tetrahedron: Asymmetry . Sep2007, Vol. 18 Issue 18, p2139-2146. 8p. - Publication Year :
- 2007
-
Abstract
- Abstract: 3,6-Di-O-methanesulfonyl-2,5-anhydro-l-idofuranose dimethyl acetal 9 was reacted with NaN3 in DMF to give 6-azido substituted carbohydrate 10 selectively. A series of 6-amino-isonucleosides 4a–d were synthesized by the reaction of nucleobases with epoxide 13, followed by hydrolysis, reduction, and deprotection, in good yield. [Copyright &y& Elsevier]
- Subjects :
- *ORGANIC compounds
*CARBON compounds
*ORGANIC chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 18
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 27050498
- Full Text :
- https://doi.org/10.1016/j.tetasy.2007.08.032