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LSD1 and the chemistry of histone demethylation
- Source :
-
Current Opinion in Chemical Biology . Oct2007, Vol. 11 Issue 5, p561-568. 8p. - Publication Year :
- 2007
-
Abstract
- The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis. [Copyright &y& Elsevier]
- Subjects :
- *HISTONES
*FLAVINS
*OXIDASES
*CHROMATIN
*ENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 13675931
- Volume :
- 11
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Chemical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 27155597
- Full Text :
- https://doi.org/10.1016/j.cbpa.2007.07.014