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Copper-Catalyzed Arylation of Heterocycle C—H Bonds.
- Source :
-
Journal of the American Chemical Society . 10/17/2007, Vol. 129 Issue 41, p12404-12405. 2p. 3 Charts. - Publication Year :
- 2007
-
Abstract
- The article examines the effect of copper salts on the regioselectivity of palladium-catalyzed electron-rich heterocycle arylation. The said effect may arise from the involvement of organocopper intermediates in the reaction and this presumed intermediate can generate without a palladium cocatalyst that will become a cheap and efficient method for heterocycle arylation. Moreover, the best results were obtained by using a combination of lithium t-butoxide base aryl iodide coupling partner.
- Subjects :
- *COPPER salts
*ARYLATION
*PALLADIUM catalysts
*ORGANIC synthesis
*COPPER catalysts
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 129
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 27235845
- Full Text :
- https://doi.org/10.1021/ja075802+