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DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
- Source :
-
Journal of Cell Biology . 10/22/2007, Vol. 179 Issue 2, p183-186. 4p. - Publication Year :
- 2007
-
Abstract
- The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOSPHORYLATION
*PROTEIN kinases
*DNA
*ENZYMES
*DNA repair
*DNA damage
Subjects
Details
- Language :
- English
- ISSN :
- 00219525
- Volume :
- 179
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 27330476
- Full Text :
- https://doi.org/10.1083/jcb.200705106