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DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Authors :
Weterings, Eric
Chen, David J.
Source :
Journal of Cell Biology. 10/22/2007, Vol. 179 Issue 2, p183-186. 4p.
Publication Year :
2007

Abstract

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00219525
Volume :
179
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Cell Biology
Publication Type :
Academic Journal
Accession number :
27330476
Full Text :
https://doi.org/10.1083/jcb.200705106