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GM-CSF DNA: An adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine
- Source :
-
Virology . Dec2007, Vol. 369 Issue 1, p153-167. 15p. - Publication Year :
- 2007
-
Abstract
- Abstract: Single intradermal or intramuscular inoculations of GM-CSF DNA with the DNA prime for a simian–human immunodeficiency virus (SHIV)-89.6 vaccine, which consists of DNA priming followed by modified vaccinia Ankara (MVA) boosting, increased protection of both the blood and intestines against the acute phase of an intrarectal SHIV-89.6P challenge. GM-CSF appeared to contribute to protection by enhancing two antibody responses: the avidity maturation of anti-Env IgG in blood (p =<0.01) and the presence of long lasting anti-viral IgA in rectal secretions (p <0.01). The avidity of anti-Env IgG showed strong correlations with protection both pre and post challenge. Animals with the highest avidity anti-Env Ab had 1000-fold reductions in peak viremia over those with the lowest avidity anti-Env Ab. The enhanced IgA response was associated with the best protection, but did not achieve significance. [Copyright &y& Elsevier]
- Subjects :
- *VACCINATION
*DNA
*IMMUNODEFICIENCY
*VACCINIA
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Volume :
- 369
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 27334228
- Full Text :
- https://doi.org/10.1016/j.virol.2007.07.017