Highly Enantioselective Insertion of Carbenoids into O—H Bonds of Phenols: An Efficient Approach to Chiral α-Aryloxycarboxylic Esters.

The article discusses the highly enantio selective insertion of carbenoids into oxygen-hydrogen bonds phenols, which is considered an effective approach to chiral α-aryloxycarboxylic esters. It is inferred that the enatioselectivity waned when the Cu/biazaferrocene catalyst was applied to phenol substrates. Moreover, the optically active α-arloxypropionates and the related acids were synthesized conveniently using the copper complexes of chiral spiro bisoxazolines as crystalysts.