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Antibacterial resistance patterns in Streptococcus pneumoniae isolated from elderly patients: PROTEKT years 1–5 (1999–2004)
- Source :
-
International Journal of Antimicrobial Agents . Dec2007, Vol. 30 Issue 6, p546-550. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: The antibacterial susceptibilities of 6646 Streptococcus pneumoniae isolates collected in 38 countries from patients ≥65 years of age with community-acquired respiratory tract infections (RTIs) during years 1–5 of the PROTEKT study (1999–2004) were analysed. Rates of erythromycin resistance (36.0%), penicillin non-susceptibility (31.3%; 20.2% resistant plus 11.1% intermediately susceptible) and resistance to multiple antibacterials (37.2%) were stable over the 5 years. The most common macrolide resistance mechanism was erm(B) (61.4%); erm(B)+ mef(A) strains increased from 5.4% (year 1) to 7.4% (year 5) (P =0.037). Overall, 37.2% of isolates exhibited resistance to two or more antibacterials, including 15.9% resistant to both penicillin and erythromycin. Antibacterial resistance was highest in the Far East. Telithromycin resistance was rare (0.12%). Appropriate alternative empirical first-line therapies may be required for treating community-acquired RTIs in the elderly. [Copyright &y& Elsevier]
- Subjects :
- *ANTIBIOTICS
*STREPTOCOCCUS pneumoniae
*RESPIRATORY infections
*ERYTHROMYCIN
Subjects
Details
- Language :
- English
- ISSN :
- 09248579
- Volume :
- 30
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- International Journal of Antimicrobial Agents
- Publication Type :
- Academic Journal
- Accession number :
- 27445382
- Full Text :
- https://doi.org/10.1016/j.ijantimicag.2007.07.025