Back to Search
Start Over
Three decades of psoriasis research: where has it led us?
- Source :
-
Clinics in Dermatology . Nov2007, Vol. 25 Issue 6, p504-509. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Psoriasis is a common chronic skin disease. Its pathogenesis has intensively been investigated in the last 3 decades. In the 1970s, the observed increased proliferation of keratinocytes and their altered differentiation were considered to be the most important signs and causes of psoriatic skin lesions. Since the early 1980s, T cells slid into the focus of psoriasis research. It was then postulated that a subpopulation of T cells, so-called T1 cells, and their prominent cytokine interferon-γ, had a dominant role in the pathogenesis of psoriasis. In the last decade, new data regarding macrophages and dendritic cells and the high therapeutic success of anti–tumor necrosis factor α biologics led to the assumption that antigen-presenting cells are important not only in the induction of psoriasis but also in its maintenance. The knowledge gained over the past 3 decades let us postulate that psoriasis is an immunologically induced, overshot, regeneration-like reaction of the skin in which various cells play a dominant role at different stages. This hypothesis is also supported by the very recent discoveries about interleukin (IL)-22, IL-20, and IL-23. [Copyright &y& Elsevier]
- Subjects :
- *SKIN diseases
*CELLS
*T cells
*KERATINOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 0738081X
- Volume :
- 25
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Clinics in Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 27531591
- Full Text :
- https://doi.org/10.1016/j.clindermatol.2007.08.002