The Role of Vascular Cell Adhesion Molecule 1/Very Late Activation Antigen 4 in Endothelial Progenitor Cell Recruitment to Rheumatoid Arthritis Synovium.

Authors :: Silverman, Matthew D.
Haas, Christian S.
Rad, Ali M.
Arbab, Ali S.
Koch, Alisa E.
Source :: Arthritis & Rheumatism. Jun2007, Vol. 56 Issue 6, p1817-1826. 10p. 2 Diagrams, 6 Graphs.
Publication Year :: 2007
Abstract: The article focuses on a study which investigated the hypothesis that endothelial progenitor cells (EPCs) selectively home to inflamed joint tissue and may perpetuate synovial neovascularization. The neovascularization and EPC accumulation in mouse ankle synovium was measured using a collagen-induced arthritis (CIA) model. It was found that cells bearing EPC markers were significantly increased in peripheral blood and accumulated in inflamed synovial pannus, in mice with CIA.

Subjects :: *CELLS
*TISSUES
*NEOVASCULARIZATION
*SYNOVIAL membranes
*JOINTS (Anatomy)
*ARTHRITIS
*ANKLE
*EXTRACELLULAR matrix proteins

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