Back to Search
Start Over
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes
- Source :
-
Molecular & Cellular Endocrinology . Dec2007, Vol. 279 Issue 1/2, p1-8. 8p. - Publication Year :
- 2007
-
Abstract
- Abstract: WISP3 is essential for maintaining cartilage integrity mainly by regulating the expression of collagen II, and mutations of WISP3 linked to spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA) can compromise this function and lead to cartilage loss. The aim of this study was to evaluate the effect of WISP3 on insulin-like growth factor (IGF) signaling in human chondrocytes, investigate whether WISP3 up-regulates collagen II through the IGF signaling pathway, and compare IGF signaling between wild-type and mutant WISP3. Experimental results suggest that WISP3 up-regulates collagen II expression and inhibits the activation of IGF-IR, IRS-1, and ERK kinase in human chondrocytes, and mutation of WISP3 augments IGF signaling in human chondrocytes. In addition to the IGF signaling pathway, WISP3 might up-regulate collagen II expression through an IGF-independent signaling cascade. [Copyright &y& Elsevier]
- Subjects :
- *CARTILAGE cells
*GROWTH factors
*DYSPLASIA
*CARTILAGE
Subjects
Details
- Language :
- English
- ISSN :
- 03037207
- Volume :
- 279
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Molecular & Cellular Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 27561974
- Full Text :
- https://doi.org/10.1016/j.mce.2007.08.007