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Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses
- Source :
-
Seminars in Cancer Biology . Dec2007, Vol. 17 Issue 6, p413-421. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: In this paper, we focus our attention on the relevance of HLA-G in cancer in the light of our recent advances on the expression and immunological function of HLA-G. Regarding HLA-G function, we recently showed that in addition to its direct inhibitory effects on T, APC and NK function, HLA-G induces suppressor cells via two distinct processes: (i) either by cell differentiation of naïve T cells into lasting suppressor T cells or (ii) by rapid transfer of HLA-G from APC or tumor cells to T or NK cells converting them into temporary HLA-G-positive suppressor cells. Regarding HLA-G expression, we described that tumor-microenvironment factors such as hypoxia, IDO and, TNF-α regulate the expression of HLA-G by tumor cells in a way that favors tumor escape from NK lysis. These findings reinforce the role of HLA-G as one mechanism of tumor-driven immune evasion and provide potential targets for testing novel anticancer treatment strategies. [Copyright &y& Elsevier]
- Subjects :
- *T cells
*TUMORS
*CANCER cells
*LYMPHOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 1044579X
- Volume :
- 17
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Seminars in Cancer Biology
- Publication Type :
- Academic Journal
- Accession number :
- 27614923
- Full Text :
- https://doi.org/10.1016/j.semcancer.2007.07.003