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Motor disorder in Huntington's disease begins as a dysfunction in error feedback control.
- Source :
-
Nature . 2/3/2000, Vol. 403 Issue 6769, p544. 6p. 3 Diagrams, 22 Graphs. - Publication Year :
- 2000
-
Abstract
- Reports that movement jerkiness, which characterizes the smoothness and efficiency of motion was a sensitive indicator of presymptomatic Huntington's disease (HD). Observation that a large fraction of asymptomatic HD gene-carriers displayed elevated jerk even when more than seven years remained until predicted disease onset; Suggestion that a dysfunction in error correction characterizes the motor control deficit in early HD.
- Subjects :
- *HUNTINGTON disease
*MOTION
*MOTOR ability
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 403
- Issue :
- 6769
- Database :
- Academic Search Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 2762365
- Full Text :
- https://doi.org/10.1038/35000576