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MTHFR polymorphisms’ influence on outcome and toxicity in acute lymphoblastic leukemia patients
- Source :
-
Leukemia Research . Dec2007, Vol. 31 Issue 12, p1669-1674. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Recently the influence of polymorphisms of different genes involved in metabolism of chemoterapic agents have been studied especially in childhood acute lymphoblastic leukemia (ALL). We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms on time to relapse and survival and on methotrexate (MTX) toxicity in 82 ALL adult patients. Relapse free survival and event free survival between homozygous wild-type and variant patients in both polymorphisms were not significantly different. However, we observed an association between 677TT variant and survival in a subset of ALL patients homogenously treated with MTX-based maintenance (p =0.02). In the same subgroup we confirmed the role of 677TT variant on toxicity during MTX treatment (p =0.003). [Copyright &y& Elsevier]
- Subjects :
- *LYMPHOBLASTIC leukemia
*LYMPHOCYTIC leukemia
*BIOCHEMISTRY
*ANTINEOPLASTIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 31
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 27626797
- Full Text :
- https://doi.org/10.1016/j.leukres.2007.03.028