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Pepitope: epitope mapping from affinity-selected peptides.
- Source :
-
Bioinformatics . Dec2007, Vol. 23 Issue 23, p3244-3244. 1p. - Publication Year :
- 2007
-
Abstract
- Identifying the epitope to which an antibody binds is central for many immunological applications such as drug design and vaccine development. The Pepitope server is a web-based tool that aims at predicting discontinuous epitopes based on a set of peptides that were affinity-selected against a monoclonal antibody of interest. The server implements three different algorithms for epitope mapping: PepSurf, Mapitope, and a combination of the two. The rationale behind these algorithms is that the set of peptides mimics the genuine epitope in terms of physicochemical properties and spatial organization. When the three-dimensional (3D) structure of the antigen is known, the information in these peptides can be used to computationally infer the corresponding epitope. A user-friendly web interface and a graphical tool that allows viewing the predicted epitopes were developed. Pepitope can also be applied for inferring other types of protein–protein interactions beyond the immunological context, and as a general tool for aligning linear sequences to a 3D structure. Availability: http://pepitope.tau.ac.il/ Contact: talp@post.tau.ac.il [ABSTRACT FROM AUTHOR]
- Subjects :
- *EPITOPES
*PEPTIDE drugs
*IMMUNOGLOBULINS
*PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 13674803
- Volume :
- 23
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 27686061
- Full Text :
- https://doi.org/10.1093/bioinformatics/btm493