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Therapeutic applications of mesenchymal stromal cells
- Source :
-
Seminars in Cell & Developmental Biology . Dec2007, Vol. 18 Issue 6, p846-858. 13p. - Publication Year :
- 2007
-
Abstract
- Abstract: Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an “off-the-shelf” therapeutic product. [Copyright &y& Elsevier]
- Subjects :
- *CELLS
*STEM cells
*PRESERVATION of organs, tissues, etc.
*CLINICAL trials
Subjects
Details
- Language :
- English
- ISSN :
- 10849521
- Volume :
- 18
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Seminars in Cell & Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 27692150
- Full Text :
- https://doi.org/10.1016/j.semcdb.2007.09.012