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Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.
- Source :
-
Immunology & Cell Biology . Nov/Dec2007, Vol. 85 Issue 8, p603-609. 7p. 2 Black and White Photographs, 4 Graphs. - Publication Year :
- 2007
-
Abstract
- We have recently described the molecular basis of HIV-1 resistance factor (HRF)-mediated anti-viral activity in primary and transformed CD4 T cells. HRF(+) cell culture supernatants or partially purified HRF were found to incapacitate the formation of the NF-κB/DNA complex, which is indispensable for long terminal promoter-driven transcription of virus genes. In this study, we tested whether HRF might have much broader activity against other organisms whose pathogenesis is linked to NF-κB activation. Specifically, we tested the effects of HRF on the NF-κB-mediated responses of primary macrophages to HIV-1 or several bacterial antigens. We found that exposure to HRF inhibited HIV-1 expression in macrophages and also induced the production of HRF-like activity by macrophages, which prevented replication of virus in HIV-1-infected peripheral blood lymphocytes cultured in the adjacent compartment. We investigated the mechanism of this inhibition and found that HRF impeded NF-κB/DNA binding in macrophages induced by either HIV-1 or lipopolysaccharide from several bacteria species, resulting in impaired tumor necrosis factor-alpha responses to these organisms.Immunology and Cell Biology (2007) 85, 603–609; doi:10.1038/sj.icb.7100092; published online 17 July 2007 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 85
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 27741991
- Full Text :
- https://doi.org/10.1038/sj.icb.7100092