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Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells.
- Source :
-
Transplant Immunology . Jan2008, Vol. 18 Issue 3, p208-219. 12p. - Publication Year :
- 2008
-
Abstract
- Despite recent extensive studies, the molecular mechanism through which DCs induce allograft tolerance largely remains poorly understood. In the current study, we presented strong evidence supporting a role for IDO in DC-mediated allograft tolerance. Pre-treatment of recipient mice with IDO-transduced donor-specific BMDCs induced skin allograft tolerance in an antigen-dependent manner. Our data suggest that IDO-expressing DCs may regulate a delicate balance of cytokines that favors the differentiation of naïve CD4+ T cells into Tregs instead of CD4+ effector T cells. In addition, BMDCs with forced IDO expression also have higher capability to expand natural Tregs. In consistent with the observation of augmented Tregs detected in the recipient mice, the capacity for splenic T cell alloresponse was significantly reduced in recipient mice pre-treated with IDO-transduced BMDCs. Furthermore, the expression of inflammatory cytokines such as IL-2, IFN±γ, IL-6, IL-l 7A and IL-23p 19, in splenic T cells of these recipient mice, was significantly lower as compared to that of recipient mice pre-treated with either GFP-transduced BMDCs or untransduced BMDCs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09663274
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Transplant Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28060360
- Full Text :
- https://doi.org/10.1016/j.trim.2007.08.006