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Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults
- Source :
-
Vaccine . Jan2008, Vol. 26 Issue 2, p215-223. 9p. - Publication Year :
- 2008
-
Abstract
- Summary: We evaluated EP HIV-1090 vaccine, a DNA plasmid encoding 21 cytotoxic T-lymphocyte (CTL) epitopes of human immunodeficiency virus type 1 (HIV-1) and the pan-DR helper T-lymphocyte epitope (PADRE), in a dose escalation, randomized, double-blinded, placebo-controlled Phase 1 trial. Vaccine, at 0.5, 2.0, or 4.0mg doses, or placebo was injected four times over 6 months. Forty-two healthy, HIV-1-uninfected adults were enrolled. Using an interferon-γ ELISPOT assay, a response to PADRE was detected in one vaccine recipient. Three vaccine recipients raised anti-HIV-1 CD8+ CTL measured by chromium-release assay. The vaccine was safe and well-tolerated, but only weakly immunogenic. [Copyright &y& Elsevier]
- Subjects :
- *LYMPHOCYTES
*EPITOPES
*INTERFERONS
*PLASMIDS
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 28078765
- Full Text :
- https://doi.org/10.1016/j.vaccine.2007.10.061