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Angiotensin II-induced vasodilation via type 2 receptor: Role of bradykinin and nitric oxide
- Source :
-
International Immunopharmacology . Feb2008, Vol. 8 Issue 2, p312-318. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation. [Copyright &y& Elsevier]
- Subjects :
- *ANGIOTENSIN II
*CARDIOVASCULAR diseases
*HYPERTENSION
*BRADYKININ
*NITRIC oxide
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 8
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28137525
- Full Text :
- https://doi.org/10.1016/j.intimp.2007.06.012