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Role of Raloxifene as a Potent Inhibitor of Experimental Postmenopausal Polyarthritis and Osteoporosis.
- Source :
-
Arthritis & Rheumatism . Oct2007, Vol. 56 Issue 10, p3261-3270. 10p. 1 Black and White Photograph, 1 Chart, 5 Graphs. - Publication Year :
- 2007
-
Abstract
- The article presents a study which tested the hypothesis that a selective estrogen receptor modulator (SERM), the raloxifene analog LY117018, could be beneficial in the treatment of both arthritis and osteoporosis using a mouse model of human rheumatoid arthritis (RA). The researchers found that in a well-established model of post-menopausal RA, the raloxifene analog LY117018 potently inhibits the progression of arthritis and the associated development of osteoporosis, both in a prophylactic and in a therapeutic regimen.
Details
- Language :
- English
- ISSN :
- 00043591
- Volume :
- 56
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Arthritis & Rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 28145710
- Full Text :
- https://doi.org/10.1002/art.22873