Back to Search
Start Over
Chiral ionic liquid-catalyzed Biginelli reaction: stereoselective synthesis of polyfunctionalized perhydropyrimidines
- Source :
-
Tetrahedron . Feb2008, Vol. 64 Issue 7, p1420-1429. 10p. - Publication Year :
- 2008
-
Abstract
- Abstract: A chiral ionic liquid-catalyzed, efficient and unprecedented version of the Biginelli reaction using new variants of its active methylene component, viz. 2-phenyl-1,3-oxazol-5-one/2-methyl-2-phenyl-1,3-oxathiolan-5-one, with aromatic aldehydes and urea/thiourea enantio- and diastereoselectively, yields 5-amino-/mercaptoperhydropyrimidines. This three-component domino cyclocondensation reaction is effected via ring transformation of an isolable intermediate in a one-pot procedure. [Copyright &y& Elsevier]
- Subjects :
- *CHIRALITY
*ORGANONITROGEN compounds
*CHEMICAL reactions
*TETRAHEDRA
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 64
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 28148802
- Full Text :
- https://doi.org/10.1016/j.tet.2007.11.044