Back to Search
Start Over
5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats
- Source :
-
Neuroscience Letters . Jan2008, Vol. 430 Issue 3, p191-196. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: Numerous studies support a role for the endogenous 5-hydroxytryptamine (5-HT) system in the hypothermic effect of capsaicin. None of those studies, however, selectively delineate a role for 5-HT reuptake or 5-HT receptors in this regard. In the present investigation, we determined if the blockade of 5-HT reuptake or the activation of 5-HT1A or 5-HT2 receptors modulates capsaicin-evoked hypothermia. The administration of capsaicin (0.2–1mg/kg, i.m.) produced dose-related hypothermia. Fluoxetine (10mg/kg, i.p.), a selective serotonin reuptake inhibitor (SSRI), did not affect body temperature. For combined administration, pretreatment with fluoxetine (10mg/kg, i.p.) significantly attenuated the hypothermia caused by capsaicin (0.5 and 1mg/kg, i.m.). For the 5-HT receptor experiments, we pretreated rats with either WAY 100635, a 5-HT1A receptor antagonist, or mianserin, a 5-HT2 receptor antagonist, and then administered a fixed, hypothermic dose of capsaicin (1mg/kg, i.m.). WAY 100635 (1mg/kg, s.c.) administration did not affect capsaicin-evoked hypothermia. This indicates that 5-HT1A receptor activation does not play a major role in the hypothermic effect of capsaicin. In contrast, pretreatment with mianserin (10mg/kg, i.p.) enhanced the hypothermic effect of capsaicin (1mg/kg, i.m.). The present data reveal that capsaicin-evoked hypothermia in rats is attenuated by the blockade of 5-HT reuptake and enhanced by the antagonism of 5-HT2 receptors. [Copyright &y& Elsevier]
- Subjects :
- *SEROTONIN uptake inhibitors
*HYPOTHERMIA
*BODY temperature
*CRYOBIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 430
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 28404391
- Full Text :
- https://doi.org/10.1016/j.neulet.2007.10.033