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The repeated immobilization stress increases IL-1β immunoreactivities in only neuron, but not astrocyte or microglia in hippocampal CA1 region, striatum and paraventricular nucleus
- Source :
-
Neuroscience Letters . Jan2008, Vol. 430 Issue 3, p258-263. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: The effect of repeated immobilization stress (RIS) on the expression of interleukin-1β (IL-1β) and types of cells that express IL-1β in hippocampal CA1 region, striatum and paraventricular nucleus (PVN) were investigated in ICR mice. The RIS was induced daily for 2h for 4 consecutive days. In the immunohistochemical study, RIS increased IL-1β immunoreactivities (IR) in the hippocampal CA1 region and striatum and PVN. The RIS also increased glial fibrillary acidic protein (GFAP) IR and complement receptor type 3 (OX-42) IR in the hippocampal CA1 regions and striatum but not PVN. In confocal immunofluorescence study, the IL-1β IR increased by RIS were colocalized with only NeuN, but not GFAP or OX-42 in the hippocampal CA1 region, striatum and PVN. Our results indicate that RIS increases IL-1β IR on neuron, but not astrocyte or microglia in the hippocampal CA1 region, striatum and PVN, suggesting that the IL-1β IR on neuron may play an important role during RIS. In addition, GFAP and OX-42 increased by RIS may be involved indirectly in playing another role in the hippocampal CA1 region and striatum during RIS. [Copyright &y& Elsevier]
- Subjects :
- *MICROGLIA
*INTERLEUKIN-1
*IMMUNOCYTOCHEMISTRY
*CYTOCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 430
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 28404403
- Full Text :
- https://doi.org/10.1016/j.neulet.2007.11.006