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Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells
- Source :
-
European Journal of Pharmacology . Feb2008, Vol. 581 Issue 1/2, p47-53. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: Doxorubicin, a widely used chemotherapeutic agent, can give rise to severe cardiotoxicity by inducing cardiomyocyte apoptosis. Dracocephalum rupestre Hance, a Chinese traditional herb, has therapeutic potential for cardiovascular diseases. Naringenin-7-O-glucoside is the main active constituent of D. rupestre and there is increasing interest in its therapeutic applications. The aim of this study was to evaluate the effects of naringenin-7-O-glucoside on cardiomyocyte apoptosis induced by doxorubicin. Cell viability was detected by MTT assay. Naringenin-7-O-glucoside (10, 20, and 40 μM) significantly enhanced cardiomyocyte proliferation relative to that of doxorubicin. Furthermore, naringenin-7-O-glucoside increased the protein levels of heme oxygenase-1 (HO-1) and Bcl-2 in cardiomyocytes (as detected by Western blotting) and suppressed the mRNA expression of caspase-3 and caspase-9 (as detected by RT-PCR). These results suggest that naringenin-7-O-glucoside has protective effects against doxorubicin-induced apoptosis, effects which could underlie the use of naringenin-7-O-glucoside therapeutic agent for treating or preventing cardiomyopathy associated with doxorubicin. [Copyright &y& Elsevier]
- Subjects :
- *CELL death
*APOPTOSIS
*MESSENGER RNA
*CARDIOMYOPATHIES
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 581
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28753704
- Full Text :
- https://doi.org/10.1016/j.ejphar.2007.11.048