Back to Search
Start Over
Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets.
- Source :
-
Journal of Translational Medicine . 2006, Vol. 4, p26-23. 23p. 5 Diagrams, 1 Chart, 4 Graphs. - Publication Year :
- 2006
-
Abstract
- Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among immune cells which sways the effects of IL-2 according to the experimental or clinical condition tested. Recombinant IL-2 (rIL-2) stimulation of peripheral blood mononuclear cells (PBMC) from 47 donors of different genetic background induced generalized T cell activation and anti-apoptotic effects. Most effects were dependent upon interactions among immune cells. Specialized functions of CD4 and CD8 T cells were less dependent upon and often dampened by the presence of other PBMC populations. In particular, cytotoxic T cell effector function was variably affected with a component strictly dependent upon the direct stimulation of CD8 T cells in the absence of other PBMC. This observation may provide a roadmap for the interpretation of the discrepant biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-2
*T cells
*CELL proliferation
*CYTOKINES
*MACROPHAGES
*CELLS
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 14795876
- Volume :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28783659
- Full Text :
- https://doi.org/10.1186/1479-5876-4-26