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Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2008, Vol. 18 Issue 3, p1223-1228. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: A series of novel peptidomimetic analogs was prepared containing cyclohexyl, phenyl, or heterocyclic groups to ostensibly orient the guanidine or mimic of an arginine in a putative melanocortin receptor ligand pharmacophore. Some binding affinity at the melanocortin receptors MC3 and MC4 was noted. In silico docking also indicated that the relative positions of the hydrogen-bonding sites and hydrophobic regions of the compounds are reasonably well matched to the receptor-binding site. This may present a lead entry into a selective series of MC4R agonists. [Copyright &y& Elsevier]
- Subjects :
- *CYCLOHEXANONES
*GUANIDINE
*ARGININE
*HYDROGEN bonding
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 29376483
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.11.109