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Blood pressure means rather than nocturnal dipping pattern are related to complications in Type 2 diabetic patients.
- Source :
-
Diabetic Medicine . Mar2008, Vol. 25 Issue 3, p308-313. 6p. 3 Charts, 1 Graph. - Publication Year :
- 2008
-
Abstract
- Aim To determine whether systolic and diastolic blood pressure (BP) means, during ambulatory BP monitoring (ABPM), are more strongly correlated with microvascular complications and echocardiographic structural alterations than night-time/daytime (N/D) BP ratio. Methods A cross-sectional study was conducted in 270 Type 2 diabetes mellitus (DM) outpatients who underwent clinical and laboratory investigations, urinary albumin excretion rate (UAER) determination, echocardiography, office and 24-h ABPM (Spacelabs 90207). Results UAER, after multivariate adjustments, was associated with office BP (systolic: R2a 0.162, P < 0.001; diastolic: R2a 0.124, P < 0.001) and ABPM (24-h systolic: R2a 0.195, P < 0.001; 24-h diastolic: R2a 0.197, P < 0.001) but not with N/D BP ratios (systolic: R2a 0.062, P = 0.080; diastolic: R2a 0.063, P = 0.069). Similar results were observed for echocardiographic parameters. The presence of retinopathy was associated only with night-time BP values [systolic means: odds ratio (OR) 1.13, 95% confidence interval (CI) 1.03–1.24 and diastolic means: OR 1.21, CI 1.04–1.40 and N/D diastolic BP ratio > 0.90, OR 3.21, CI 1.65–6.25]. Conclusions UAER and echocardiographic structural alterations had more consistent correlations of a greater magnitude with systolic BP means than with N/D BP ratios. The nocturnal BP values appear to be more relevant for diabetic retinopathy. BP measurement in patients with Type 2 DM should take into account the 24-h period rather than focusing on a specific time span of BP homeostasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 25
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30101237
- Full Text :
- https://doi.org/10.1111/j.1464-5491.2007.02354.x