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Study on controlled drug permeation of magnetic-sensitive ferrogels: Effect of Fe3O4 and PVA
- Source :
-
Journal of Controlled Release . Mar2008, Vol. 126 Issue 3, p228-236. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: A PVA-based magnetic-sensitive hydrogel (ferrogel) was fabricated by physical cross-linking through a freezing–thawing method. The influence of the constituting components, i.e., Fe3O4 and PVA, on the magnetic-sensitive behavior of the ferrogels was systematically investigated in terms of permeability coefficient (P), partition coefficient (H), space restriction and magnetization. The results show that, the P value in these ferrogels decreases and displays a magnetic sensitivity when it is subjected to magnetic field (MF), which is correlated with the change of H value. In addition, it was found that although the factor of space restriction or magnetization exerts opposite effect on resulting magnetic-sensitive behavior, the superior magnetic-sensitive behavior was observed for the ferrogels with an optimal composition of 17–34% Fe3O4 and 10–12.5% PVA, and can be well correlated with theoretical calculation from the critical parameters of available free volume per nanoparticle (V free) and magnetization. A map of magnetic-sensitive behavior was constructed, where a region with relatively stable and highly stimuli-responsive behavior in terms of the concentration of Fe3O4 was observed, however, below or above the “saturation” region (17–34% Fe3O4), a reduction in the magnetic-sensitive behavior was detected. The resulting ferrogels can be engineered with a precise control of the opening and closure of pore configuration, which allows a burst release or no-release action of therapeutically active agent to be controlled externally and magnetically. This suggests that this type of ferrogel can be considered as a class of novel magnetically-tunable drug delivery system. [Copyright &y& Elsevier]
- Subjects :
- *HYDROGELS
*MAGNETIZATION
*DRUG delivery systems
*MAGNETIC fields
Subjects
Details
- Language :
- English
- ISSN :
- 01683659
- Volume :
- 126
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Controlled Release
- Publication Type :
- Academic Journal
- Accession number :
- 30561491
- Full Text :
- https://doi.org/10.1016/j.jconrel.2007.12.006