(−)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties

Authors :: Arthurs, Claire L.
Lingley, Katharine F.
Piacenti, Michela
Stratford, Ian J.
Tatic, Tanja
Whitehead, Roger C.
Wind, Natasha S.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2008, Vol. 49 Issue 15, p2410-2413. 4p.
Publication Year :: 2008
Abstract: Abstract: Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (−)-quinic acid. The results of bioassays of the target compounds against two lung cancer cell lines, A549 and H460, are presented. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 49
Issue :: 15
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 31302989
Full Text :: https://doi.org/10.1016/j.tetlet.2008.02.059

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