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(−)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2008, Vol. 49 Issue 15, p2410-2413. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (−)-quinic acid. The results of bioassays of the target compounds against two lung cancer cell lines, A549 and H460, are presented. [Copyright &y& Elsevier]
- Subjects :
- *TUMORS
*CELL lines
*CELL culture
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 49
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31302989
- Full Text :
- https://doi.org/10.1016/j.tetlet.2008.02.059